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CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 4
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DeCS
Descriptor
English
:
Cyclic Nucleotide Phosphodiesterases, Type 4
Descriptor
Spanish
:
Fosfodiesterasas de Nucleótidos Cíclicos Tipo 4
Descriptor
Portuguese
:
Nucleotídeo Cíclico Fosfodiesterase do Tipo 4
Tree Number:
D08.811.277.352.640.150.400
D12.644.360.008.400
D12.776.476.008.400
Definition
English
:
A cyclic nucleotide phosphodiesterase subfamily that is found predominantly in inflammatory cells and may play a role in the regulation of
CELL-MEDIATED IMMUNITY
. The enzyme
family
includes over twenty different variants that occur due to multiple
ALTERNATIVE SPLICING
of the mRNA of at least four different genes.
Entry Combination - descr/qualif
English
:
Cyclic Nucleotide Phosphodiesterases, Type 4
/
antagonists & inhibitors
use
Phosphodiesterase 4 Inhibitors
History Note
English
:
2008(1981)
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AN
analysis
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DF
deficiency
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
52679
Unique Identifier:
D054703
Occurrence in VHL
:
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DeCS
CID-10
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